Feverfew is primarily known for use in prophylactic treatment of migraine headaches and associated nausea and vomiting; however, evidence to support this use is inconclusive. Feverfew has numerous other pharmacological actions, including inhibition of prostaglandin synthesis, blockage of platelet granule secretion, effects on smooth muscle, antitumor activity, inhibition of serotonin release, inhibition of histamine release, and mast cell inhibition, but information from clinical trials is limited
 
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