Bone Biology. Role of RANK, RANKL, and OPG. bone remodeling. Bone is broken down by osteoclasts, and rebuilt by osteoblasts. Receptor activator of RANKL is the mediator of bone resorption. Osteoprotegerin OPG. Paracrine and endocrine actions of bone. functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
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