chimeric antigen receptor car therapy engineered cell attacks leukemia |
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| navigate by keyword : antibody antigen apoptosis artificial bioengineering biomolecule biotechnology cancer car cd19 cell chimeric cytokine death enzyme granzyme immune immunoreceptor immunotherapy leukemia membrane neuroblastoma perforin protein receptor signal specific system tcell therapy tumor |
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| Engineered receptors on the surface of a T-lymphocyte bind specifically to CD19-antigen molecules on a leukemia cell. This activates a signal cascade in the T-cell leading to the segregation of vesicles that contain perforin and granzyme. The perforins build channels for the granzymes which enter the leukemia cell and activate finally the apoptosis cell death of the cancer cell |
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